<h1>NONMEM</h1>
<p>A fortran based non-linear mixed effects modelling software with very powerful algorithms including ODE solvers. It is a commercial software made by ICON plc that is widely used in the pharmacometrics community. It has a steep learning curve but once you get used to it, you'll probably not need to use another non-linear mixed effects modelling software. It needs to be used alongside other statistical tools like <a href="https://www.r-project.org/" rel="nofollow noreferrer">R</a> to analyse and visualise modelling results. It can also be used alongside <a href="http://psn.sourceforge.net/" rel="nofollow noreferrer">PsN</a> for automated covariate analysis and visual predictive checks, simulation, etc. For more on NONMEM, visit <a href="https://www.iconplc.com/solutions/technologies/nonmem" rel="nofollow noreferrer">ICON plc</a>.</p>
<p>This <a href="https://web.archive.org/web/20151222213234/http://accp1.org/pharmacometrics/theory.htm" rel="nofollow noreferrer">short tutorial</a> (archived) gives a very concise introduction to pharmacometrics and non-linear mixed effects modelling.</p>
